The clinical implications of endothelial dysfunction

The clinical implications of endothelial dysfunction.

Defining new approaches for the prevention and treatment of atherosclerosis is an important priority. Recently, measurement of endothelial function in patients has emerged as a useful tool for atherosclerosis research. Risk factors are associated with impaired endothelial function, and clinical syndromes relate, in part, to a loss of endothelial control of vascular homeostasis. Recent studies h...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

The Triad of Endothelial Dysfunction, Cardiovascular Disease, and Erectile Dysfunction: Clinical Implications

Piero Montorsi *, Paolo M. Ravagnani , Stefano Galli , Sarah Ghulam Ali , Alberto Briganti , Andrea Salonia , Francesco Montorsi b a Institute of Cardiology, University of Milan, Centro Cardiologico Monzino, IRCCS, Milan, Italy Department of Urology and Sexual Diseases, University Vita-Salute Ospedale S. Raffaele, Milan, Italy avai lable at www.sc iencedi rect .com journal homepage: www.europea...

Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches

Atherosclerosis is a chronic progressive vascular disease. It starts early in life, has a long asymptomatic phase, and a progression accelerated by various cardiovascular risk factors. The endothelium is an active inner layer of the blood vessel. It generates many factors that regulate vascular tone, the adhesion of circulating blood cells, smooth muscle proliferation, and inflammation, which a...

The clinical significance of endocardial endothelial dysfunction.

Endocardial endothelium (EE) is essential in the embryonic development of the heart, the optimal contractility and rhythm as well as the remodeling of the heart. Endocardial endothelium affect the contractility of cardiomyocytes through paracrine signaling substances such as nitric oxide (NO), endothelin (ET-1), prostaglandins (PGI2, PGF2, PGE2) and angiotensin II (ANG II). Typical lesions of e...